Manipulating the Type 1 Diabetes Disease Process, Man Versus Mouse

Manipulating the type 1 diabetes disease process, man versus mouse.

I n their article in this month's issue of Diabetes Care, Hummell et al. (1) tested the hypothesis that gluten is a driving antigen for type 1 diabetes–associated is-let autoimmunity. They convincingly demonstrated that elimination of dietary gluten for 12 months in humans positive for at least two type 1 diabetes–associated autoantibodies does not consistently alter the titers of these antibod...

Immunogenetics of Type 1 Diabetes in Man

Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man

Type 1 diabetes—or, more accurately, type 1A diabetes—is thought to arise from selective immunologically mediated destruction of the insulin-producing -cells in the pancreatic islets of Langerhans with consequent insulin deficiency (1). This occurs in individuals in whom genetic susceptibility outweighs genetic protection and is probably initiated by environmental factors not yet clearly define...

Mouse Models for Type 1 Diabetes.

Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researche...

Type 1 Diabetes Mellitus, Celiac Disease, and Selective IgA Deficiency: a Case Report

Patients with Type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. Untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. Therefore, we report a 9-year-old girl with Coeliac disease, diabetes type 1 and Selective IgA deficiency. A 9-year-old female patient presented in august 2...